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Long-term survival of monkey with transplanted pig kidney offers hope in alternative organ search: Scientists_我的网站

A |     Harvard-affiliated scientists say they have been able to keep a monkey alive for two years with a genetically engineered pig kidney. Although preliminary, transplant experts say this research is an important milestone in the search for an alternative source of organs.Scientists are hopeful that one day, genetically modified organs grown in pigs may be able to significantly extend the life of people with end-stage organ failure.In recent months, other high-profile research teams at New York University and the University of Alabama at Birmingham announced successful transplants of genetically modified pig-kidneys into brain dead human donors. But those experiments ended after a few weeks."Duration of survival has been an Achilles heel of genetically modified pig organs to date due to a combination of rejection and opportunistic infections," said Dr. Peter Chin-Hong, director of the transplant infectious disease program at University of California, San Francisco.This new research, published in Nature, represents the longest period of time that scientists have been able to keep a non-human primate research animal alive."This proof-of-concept study provides real hope that transplantation of porcine [pig] donor kidneys into humans is very much on the horizon," Chin-Hong said.Still, experts cautioned that this new research was preliminary, and the idea of pig-grown organs is likely several years away from becoming a reality."If ultimately proved successful in human organ recipients - which is still years away at this point - this could be one of the key advances needed to make xenotransplantation a reality in clinical practice," said Dr. Josh Levitsky, president of the American Society of Transplantation.The new research was led by eGenesis, a company co-founded by Harvard geneticist George Church. In a press release, scientists at eGenesis said the new research will help lay the groundwork for formal clinical trials.In prepared remarks, eGenesis CEO Michael Curtis, PhD, said the company is focused on "improving long-term survival for transplant recipients from months to years."Eventually, the hope is that transplant doctors will be able to use genetically modified pig organs instead of solely relying on deceased human organ donors."Among all solid organs transplanted, kidneys are most sought after, expected to increase in demand further, and there is a significant shortfall of organs leading to premature deaths," Chin-Hong said.Every day, 17 people die waiting on the organ transplant list, according to the Health Resources & Services Administration. There are currently more than 100,000 people waiting on the national transplant list and a new person is added to the list every 10 minutes.。

B |     

NBA季后赛首轮G1，勇士95-85战胜火箭。这场比赛勇士第二节主导局势拉开分差，末节在火箭连续追分的时候可以稳住优势，最终拿下了胜利。赛后勇士迎来3喜1忧。

巴特勒的发挥是真猛。来到季后赛之后，他展现了自己足够强势的杀伤力。全场比赛25分7篮板6助攻5抢断，他在进攻端的杀伤力拉满，关键时刻也可以站出来。同时巴特勒送出5个抢断，是队史首位代表球队第一次出战季后赛就达成这种成就的球员。按照这样的表现，巴特勒确实不贵，打这种比赛刚刚好。

库里的发挥也非常强劲。19中12轰31分6板3助，这种得分爆发力已经足够完美了。毕竟火箭给到的还是高压防守，他可以不断打进各种神仙球，对手根本防不住。只要库里保持这种手感，这对于勇士来说就是巨大的带动。

C | 只有库里暴走的比赛，勇士才能锁定胜利。

而且角色球员的辅助效果也非常好。

D | 一个是波杰，他13中5，三分8中3得到14分8篮板5助攻2抢断。

E | 看数据不怎么样，最后时刻他可以连续打进关键球，甚至对于篮板球的拼抢也不错，他给到了球迷希望，正负值还是全队最高。穆迪给到的攻守带动也可以，不仅打进关键三分，防守压迫性也可以，这两个人在关键时刻给到了核心球员解压。

F |

就是格林太容易自爆了。

G | 只要来到最后时刻，他经常因为自己的失误导致球队输球。特别是领先24分抢下篮板后的失误，差点让火箭扭转局势。当然他在防守端的发挥是没有任何问题的，就是这个脑子经常在决胜期犯浑。

H | 这种麻烦后续肯定会持续存在，这对于勇士就是定时炸弹，同时进攻端的状态也需要回暖一下。

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